Использование комбинированного ПЦР-подхода для выявления транслокаций генов ALK, ROS1, RET в опухолях лёгкого

The discovery of recurrent EGFR mutations, ALK and ROS1 translocations, together with the development effective targeted drugs, has become a real breakthrough in treatment lung cancer. Molecular diagnosis alteration these genes already mandatory part evaluating patients non-small cell paper presents combined diagnostic approach, which allows identification known chimeric transcripts new variants translocations. Using this technique, we identified eight fusions that had not been previously described literature. Here, analyze spectrum translocations receptor tyrosine kinases ALK, ROS1, RET Russian population, seems relevant connection ethnic geographic heterogeneity